Regulatory Elements in Noncoding DNA in the Chromosome 9p21 Locus
نویسندگان
چکیده
منابع مشابه
Regulatory elements in noncoding DNA in the chromosome 9p21 locus.
Study Hypothesis A novel locus on chromosome 9p21 has been identified in numerous genome-wide association studies as the most highly associated with coronary artery disease (CAD) and myocardial infarction. Understanding the mechanism by which the locus influences disease has been a challenge because the locus lies entirely within noncoding DNA—in a so-called “gene desert” at a long distance fro...
متن کاملAssociation of variation in the chromosome 9p21 locus with myocardial infarction versus chronic coronary artery disease.
BACKGROUND A chromosome 9p21 locus is associated with coronary heart disease in 25 independent populations, but multiple clinically distinct phenotypes have been evaluated. Using angiographic coronary artery disease (CAD) phenotyping, this study evaluated whether 9p21 single-nucleotide polymorphisms predict ischemic events (eg, myocardial infarction [MI]) among CAD patients. METHODS AND RESUL...
متن کاملAlterations of p16-pRb pathway and chromosome locus 9p21-22 in sporadic invasive breast carcinomas.
The p16-pRb pathway represents a vital cell-cycle checkpoint. In the present study we investigated the alterations of this G1-phase protein pathway using immunohistochemical and molecular methods in a series of 55 breast carcinomas and correlated the findings with clinicopathological features of the patients. Furthermore, we examined its relationship with the status of the chromosomal region 9p...
متن کاملThe chromosome 9p21 risk locus is associated with angiographic severity and progression of coronary artery disease.
AIMS we tested the hypothesis that the 9p21 risk locus promotes atherosclerosis by examining the association between rs10757278 and coronary artery disease (CAD) severity and progression determined by semi-quantitative angiographic scores. METHODS AND RESULTS the rs10757278 single nucleotide polymorphism (SNP) was genotyped as the marker for the 9p21 locus in 2334 Caucasian patients undergoin...
متن کاملAssociation Study of rs1333040 and rs1004638 Polymorphisms in the 9p21 Locus with Coronary Artery Disease in Southwest of Iran
Background: Coronary artery disease (CAD) is a multifactorial and heterogenic disease. Recently, genome-wide association studies have reported that rs1333040 (C/T) and rs1004638 (A/T) single nucleotide polymorphisms (SNPs) in the 9p21 locus have very strong association with CAD. This study aimed to examine these associations in Southwest of Iran. Methods: Blood samples were collected from 200 C...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation: Cardiovascular Genetics
سال: 2011
ISSN: 1942-325X,1942-3268
DOI: 10.1161/circgenetics.111.960500